Comparative Evaluation of Green Tea Pretreatment on Serum Biochemical Markers in Gentamicin-Induced Nephrotoxicity among Long Evans Rats
Rahatul Jannat Nishat
Assistant Professor Department of Physiology Fazlur Rahman Medical College Dhaka, Bangladesh E-mail: dr.rahatulnishat@gmail.com
Mohammad Rabiul Halim
Consultant Department oF ICU Fazlur Rahman Medical College Dhaka, Bangladesh
Rifat Chowdhury
Lecturer, Department of Physiology Government Homeopathic Medical College Dhaka, Bangladesh
Tarak Nath Das
Assistant Professor & Head Department of Physiology Jashore Medical College Jashore, Bangladesh
Asfaq Rafed Rahman
Assistant Professor Department of Physiology Manikganj Medical College Dhaka, Bangladesh
Keywords: Green tea extract, Gentamicin, Nephrotoxicity,
Nephroprotection
Abstract
Background:
Aminoglycoside antibiotic gentamicin is a widely used clinical agent
with nephrotoxicity that is dose related. The pathogenesis of kidney
injury that occurs due to drugs is based on oxidative stress.
Objective:
Methods:
The experimental in vivo study was carried out from 1st July 2019 to
30th June 2020 in Sir Salimullah Medical College, Dhakawhere 30
healthy male Long Evans rats aged between 90-120 days. Statistical
analysis was done using SPSS v22 with ANOVA and post hoc
Bonferonni test (p ≤ 0.05).
Results:
Green tea pretreatment significantly reduced the gentamicin-induced
increases in serum creatinine (1.02±0.12 vs 1.54±0.16 mg/dL,
p<0.001), serum urea(46.2±4.9 vs 72.3±6.1mg/dL, p<0.001), and BUN
(22.1±2.4 vs 33.7±3.1mg. The pretreatment group had an intermediate
weight of the kidneys (1.14-0.20g) compared to the control group and
the gentamicin-treated group.
Conclusion:
The green tea extract is effective in providing meaningful
nephroprotective effects in gentamicin-induced kidney injury, which is
probably due to antioxidant effect.
J Rang Med Col. March 2026; Vol.11, No.1:189-195
DOI: https://doi.org/10.3329/jrpmc.v11i1.90057