Demographic and Renal Histopathological Profile of Rapidly Progressive Glomerulonephritis in Children
Mohammad Abu Hasnat
Registrar Department of Pediatric Nephrology Bangladesh Shishu Hospital & Institute Dhaka, Bangladesh Email: hasnat62@gmail.com
Shireen Afroz
Professor Department of Paediatric Nephrology Bangladesh Shishu Hospital and Institute Dhaka, Bangladesh
Keywords: Crescentic glomerulonephritis, Pediatric nephrology,
Fibrocellular crescents, Acute kidney injury
Abstract
Background:
Rapidly progressive glomerulonephritis (RPGN) is an uncommon but
severe pediatric renal disorder, and its incidence and etiological
patterns remain poorly defined.
Objective:
This study examined demographic features and renal histopathology
among affected children.
Methods:
A prospective observational study was conducted in the Department of
Paediatric Nephrology, BICH and Dhaka Shishu Hospital from July
2018 to June 2020, enrolling 28 pediatric cases displaying features of
rapidly progressive glomerulonephritisthrough non-probability
sampling.
Results:
The mean age was 9.1±1.9 years in children with more than 50%
crescents and 8.7±2.2 years in those with fewer crescents. Males
predominated in the high-crescent group, and most participants (82%)
were from rural areas. Increased cellularity, mesangial expansion, and
interstitial inflammation were frequent in both histological categories.
Most children presented with acute kidney injury stage 3, with no
significant difference between groups.
Conclusion:
RPGN in children appears to predominantly affect rural male patients in
late childhood, with severe renal dysfunction and similar
histopathological patterns across crescentic categories.
J Rang Med Col. March 2026; Vol.11, No.1:119-123