Orogenital Aphthae with Blindness- A Look Beyond The ‘Silk Road’

Behcet’s disease is a vasculitis affecting small arteries and venules, more
common in ‘Silk Route’ countries, the Mediterranean, and Japan due to
a strong genetic association with HLA-B51. Oral ulcers are common,
with genital ulcers occurring in 60%-80% of cases. Skin lesions include
erythema nodosum or acneiform, while migratory thrombophlebitis and
vasculitis also occur. Ocular involvement is common, and neurological
involvement occurs in 5%, mainly involving the brainstem with rare
renal involvement. A 32-year-old lady presented with recurrent painful,
herpetiform oral ulceration and painful genital ulceration, central retinal
artery occlusion (CRAO) of left eye and intermediate uveitis of right eye
with positive HLA-B51.